Publications

Ikeogu N, Ajibola O, Zayats R, Murooka TT

Dans la presse

2023

Identifying physiological tissue niches that support the HIV reservoir in T cells.

31 octobre 2023

Clain JA, Rabezanahary H, Racine G, Boutrais S, Soudaramourty C, Beauparlant CJ, Jenabian M, Droit A, Ancuta P, Zghidi-Abouzid O, Estaquier J.

Early ART reduces viral seeding and innate immunity in liver and lungs of SIV-infected macaques.

24 juillet 2023

Gantner P, Buranapraditkun S, Pagliuzza A, Dufour C, Pardons M, Mitchell JL, Kroon E, Sacdalan C, Tulmethakaan N, Pinyakorn S, Robb ML, Phanuphak N, Ananworanich J, Hsu D, Vasan S, Trautmann L, Fromentin R, Chomont N

HIV rapidly targets a diverse pool of CD4+ T cells to establish productive and latent infections.

14 mars 2023

Colas C, Volodina O, Béland K, Pham, TNQ, Li Y, Dallaire F, Soulard C, Lemieux W, Colamartino ABL, Tremblay-Laganière C, Dicaire R, Guimond J, Vobecky S, Poirier N, Patey N, Cohen EA, Haddad E

Generation of functional human T cell development in NOD/SCID/IL2rγnull humanized mice without using fetal tissue: Application as a model of HIV infection and persistence.

14 février 2023

Fert A, Marchand LR, Wiche Salinas TR, Ancuta P

2022

Targeting Th17 cells in HIV-1 remission / cure interventions. Trends in Immunology.

juillet 2022

Bryostatin-1 Decreases HIV-1 Infection and Viral Production in
Human Primary Macrophages.

février 2022

Hany L , Turmel M, Barat C , Ouellet M , Tremblay MJ

T cell migration potentiates HIV infection by
enhancing viral fusion and integration.

février 2022

Lopex P, Ajibola O, Pagiluzza A, Zayats R, Hon Koh W, Herschhorn A, Chomont N, Murooka T

2021

Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth

novembre 2021

Salinas TRW, Zhang Y, Sarnello D, Zhyvoloup A, Raymond Marchanda L, Planas D, Lodha M, Chatterjee D, Karwacz K, Oxenford S, Routy JP, Madsen H, Ancuta P, and Fassati A. PNAS

Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy

mars 2021

Planas D, Pagliuzza A, Ponte R, Fert A, Marchand L.R, Massanella M, Gosselin A, Mehraj V, Dupuy F.P, Isnard S, Goulet J-P, Lesage S, , Ghali M.P, Angel J, Chomont N, Routy J-P, Ancuta P. EBioMedicine.

Beyond the Absence of CD4 T-Cell Count: A Novel Genetic CD4 T-Cell Deficiency Disorder With a Contingency Plan

24 février 2021

Routy J-P, Isnard S. J Infect Dis.

Differences in HIV burden in the inflamed and non-inflamed colon from a person living with HIV and ulcerative colitis

15 février 2021

Peng X, Isnard S, Lin J, Fombuena B, Bessissow T, Chomont N, Routy J-P. J Virus Erad.

Meziane O, Alexandrova Y, Olivenstein R, Dupuy FP, Salahuddin S, Thomson E, Orlova M, Schurr E, Ancuta P, Durand M, Chomont N, Estaquier J, Bernard NF, Costiniuk CT, Jenabian M-A. J Immunol.

2020

Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy

14 décembre 2020

Meziane O, Salahuddin S, Pham TNQ, Farnos O, Pagliuzza A, Olivenstein R, Thomson E, Alexandrova Y, Orlova M, Schurr E, Ancuta P, Haddad E, Chomont N, Cohen EA, Jenabian M-A, Costiniuk CT. J Virol.

HIV Infection and Persistence in Pulmonary Mucosal Double Negative T Cells In Vivo

23 novembre 2020

Rabezanahary H, Clain J, Racine G, Andreani G, Benmadid-Laktout G, Borde C, Mammano F, Mesplèdes T, Ancuta P, Zghidi-Abouzid O, Estaquier J. J Virol.

Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques

22 octobre 2020

Planas D, Fert A, Zhang Y, Goulet J-P, Richard J, Finzi A, Julia Ruiz MJ, Marchand LR, Chatterjee D, Chen H, Raul Wiche Salinas T, Gosselin A, Cohen EA, Routy J-P, Chomont N, Ancuta P. Pathogen Immun.

Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection

30 septembre 2020

Lodge R, Bellini N, Laporte M, Salahuddin S, Routy J-P, Ancuta P, Costiniuk CT, Jenabian M-A,Cohen EA. mBio

Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107

29 septembre 2020

HIV enters deep sleep in people who naturally control the virus

septembre 2020

Chomont N. Nature

Distinct viral reservoirs in individuals with spontaneous control of HIV-1

septembre 2020

Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

7 septembre 2020

Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART

14 août 2020

Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R and Chomont N. Nature Communications

Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid.

15 mai 2020

Zhang Y, Planas D, Marchand LR, Massanella M, Chen H, Wacleche VS, Gosselin A, Goulet J-P, Filion M, Routy J-P, Chomont N and Ancuta P. Frontiers in Microbiology.

2019

Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.

13 novembre 2019

Rabezanahary H, Moukambi F, Palesch D, Clain J, Racine G, Andreani G, Benmadid-Laktout G, Zghidi-Abouzid O, Soundaramourty C, Tremblay C, Silvestri G, Estaquier J. Mucosal Immunol

Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.

12 septembre 2019

Yero A, Farnos O, Rabezanahary H, Racine G, Estaquier J, Jenabian MA. J. Virology

HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.

28 août 2019

Lopez P, Koh WH, Hnatiuk R, Murooka TT. J. Virology

HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy.

12 juin 2019

Miller RL, Ponte R, Jones BR, Kinloch NN, Omondi FH, Jenabian MA, Dupuy FP, Fromentin R, Brassard P, Mehraj V, Chomont N, Poon AFY, Joy JB, Brumme Z, Routy JP; ORCHID study group. J. Virology

Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.

21 mars 2019

Breton Y, Desrosiers V, Ouellet M, Deshiere A, Torresilla C, Cohen ÉA, Tremblay MJ. J. Virology

HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.

11 mars 2019

Cattin A, Salinas TRW, Gosselin A, Planas D, Shacklett B, Cohen EA, Ghali MP, Routy JP, Ancuta P. AIDS

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.

27 février 2019

Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N. PLoS Pathogen.

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.

18 février 2019

Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ6, Lewin SR, Routy JP, Sékaly RP, Chomont N. Nature Communications.

Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages.

7 février 2019

Shringar Rao, Raquel Amorim, Meijuan Niu, Yann Breton, Michel J. Tremblay and Andrew J. Mouland. Retrovirology.

Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.

1 février 2019

Brumme ZL, Sudderuddin H, Ziemniak C, Luzuriaga K, Jones BR, Joy JB, Cunningham CK, Greenough T, Persaud D. AIDS

Medical Assistance in Death as a Unique Opportunity to Advance HIV Cure Research.

31 janvier 2019

Sandstrom TS, Burke Schinkel SC, Angel JB. Clin Infect Dis.

HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.

19 janvier 2019

Usmani SM, Murooka TT, Deruaz M, Koh WH, Sharaf RR, Di Pilato M, Power KA, Lopez P, Hnatiuk R, Vrbanac VD, Tager AM, Allen TM, Luster AD, Mempel TR. Cell Host Microbe.

HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals.

2 janvier 2019

Omondi FH, Chandrarathna S, Mujib S, Brumme CJ, Jin SW, Sudderuddin H, Miller R, Rahimi A, Laeyendecker O, Bonner P, Yue FY, Benko E, Kovacs CM, Brockman MA, Ostrowski M, Brumme ZL. J. Virology.

2018

Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs.

30 novembre 2018

Kuang XT1, Brockman MA. Viruses.

Dual HLA B42 and B81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

27 novembre 2018

Ogunshola F, Anmole G, Miller R, Goering E, Nkosi T, Muema D, Mann J, Ismail N, Chopera D, Ndung’u T, Brockman M & Ndhlovu Z. Nature Communications.

HIV Cure Research: An example of successful advocacy by scientists for science

3 novembre, 2018

Angel, JB. Clint Invest. Med.

Bradley R. Jones, Natalie N. Kinloch, Joshua Horacsek, Bruce Ganase, Marianne Harris , P. Richard Harrigan, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Art FY Poon et Zabrina L. Brumme . PNAS

Phylogenetic approach to recover integration dates of latent HIV sequences within-host.

5 septembre 2018

The RNA surveillance protein UPF1, UPF2 and SMG6 affects HIV-1 reactivation at post-transcriptional level.

28 juin 2018

Rao S, Amorin R, Niu M, Temzi A, Mouland A. Retrovirology

The RNA surveillance protein UPF1, UPF2 and SMG6 affects HIV-1 reactivation at post-transcriptional level.

28 juin 2018

Rao S, Amorin R, Niu M, Temzi A, Mouland A. Retrovirology

Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products.

27 juin 2018

Richard K, Williams DE, de Silva ED, Brockman MA, Brumme ZL, Andersen RJ, Tietjen I. Viruses

Use of (1→3)-β-D-Glucan for diagnosis and management of invasive mycoses in HIV-infected patients.

31 mai 2018

Farhour Z, Mehraj V, Chen J, Ramendra R, Lu H, Routy JP. Mycoses. 2018 May 31;. [Epub ahead of print]

ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication.

26 mars 2018

Radetskyy R, Daher A, Gatignol A. Cytokine Growth Factor Rev. pii: S1359-6101(18)30032-7. doi: 10.1016/j.cytogfr.2018.03.007. [Epub ahead of print]

cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages.

1 mars 2018

Busca A,, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A. J Immunol

Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.

15 avril, 2018

Tietjen I, Williams DE, Read S, Kuang XT, Mwimanzi P, Wilhelm E, Markle T, Kinloch NN, Naphen CN, Tenney K, Mesplède T, Wainberg MA, Crews P, Bell B5, Andersen RJ, Brumme ZL, Brockman MA. Antiviral Res. 152:94-103. doi: 10.1016/j.antiviral.

Socio-economic status and time trends associated with early ART initiation following primary HIV infection in Montreal, Canada: 1996 to 2015.

6 fevrier 2018

Mehraj V, Cox J, Lebouché B, Costiniuk C, Cao W, Li T, Ponte R, Thomas R, Szabo J, Baril JG, Trottier B, Côté P, LeBlanc R, Bruneau J, Tremblay C, Routy JP; Montreal Primary HIV-Infection Study Group. J Int AIDS Soc. 2018 Feb;21(2). doi: 10.1002/jia2.25034.

The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis.

6 fevrier, 2018

Wacleche VS, Tremblay CL, Routy JP, Ancuta P. Viruses. 10(2). pii: E65. doi: 10.3390/v10020065.

cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages.

22 Janvier, 2018

Busca A, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A. J Immunol.pii: ji1700199. doi: 10.4049/jimmunol.1700199. [Epub ahead of print]

Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise.

17 Janvier, 2018

Plantin J, Massanella M, Chomont N. Retrovirology.15(1):9. doi: 10.1186/s12977-017-0385-y.

Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.

16 Janvier, 2018

Wong RW, Lingwood CA, Ostrowski MA, Cabral T, Cochrane A. Sci Rep. 8(1):850. doi: 10.1038/s41598-018-19298-x.

2017

Regulation of CD4 Receptor and HIV-1 Entry by MicroRNAs-221 and -222 during Differentiation of THP-1 Cells.

30 Décembre, 2017

Lodge R, Gilmore JC, Ferreira Barbosa JA, Lombard-Vadnais F, Cohen ÉA. Viruses. 10(1). pii: E13. doi: 10.3390/v10010013.

Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.

Décembre 2017

Whyte-Allman SK, Hoque MT, Jenabian MA, Routy JP, Bendayan R

Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion.

11 Décembre 2017

Proust A, Barat C, Leboeuf M, Drouin J, Tremblay MJ. J Neuroinflammation. 2017 Dec 11;14(1):242. doi: 10.1186/s12974-017-1019-y.

The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure.

8 Décembre 2017

Ranganath N, Sandstrom TS, Burke Schinkel SC, Côté SC, Angel JB. The Journal of Infectious Diseases.

Managing Expectations of an HIV Cure: What Should We Expect?

22 Nov 2017

Reinhard, RJ. AIDS Res Hum Retroviruses. doi: 10.1089/AID.2017.0247. [Epub ahead of print]

HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1.

10 Nov 2017

Rao S, Cinti A, Temzi A, Amorim R, You JC, Mouland AJ. HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1. RNA. 2017 Nov 10. pii: rna.064618.117. doi: 10.1261/rna.064618.117. [Epub ahead of print]

Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay.

5 Nov 2017

Routy JP, Mehraj V. Ann Transl Med. 2017 Nov;5(21):434. doi: 10.21037/atm.2017.08.38.

Daher A, Labbé RP, Radetskyy R, Gatignol A. Virologie. 2017. 21:211-224

The Interferon-induced Protein Kinase R: the base of a riboprotein scaffolding regulating the Human Immunodeficiency Virus.

Nov 2017

The Th17 Lineage: From Barrier Surfaces homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis.

19 Oct 2017

Sue Waclech V, Landay A, Routy JP, Ancuta P. Viruses. 19;9(10). pii: E303. doi: 10.3390/v9100303.

Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.

16 Oct 2017

Asahchop EL, Meziane O, Mamik MK, Chan WF, Branton WG, Resch L, Gill MJ, Haddad E, Guimond JV, Wainberg MA, Baker GB, Cohen EA, Power C. Retrovirology. 16;14(1):47. doi: 10.1186/s12977-017-0370-5.

Characterization of myeloid cell populations in human testes collected after sex reassignment surgery.

11 Oct 2017

Ponte R, Dupuy F, Brimo F, Mehraj V, Brassard P, Belanger M, Yurchenko E, Ali Jenabian M, Bernard NF, Routy JP, for the ORCHID study group. Journal of Reproductive Immunology. (2018) 16-24. doi: 10.1016/j.jri.2017.10.043

Elevation and persistence of CD8 T-cells in HIV infection: the Achilles heel in the ART era.

Oct 3, 2017

Cao W, Mehraj V, Kaufmann DE, Li T, Routy JP. Journal of the International AIDS Society 2016, 19(1): 20697.

Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.

Oct 3, 2017

Lodge R, Ferreira Barbosa JA, Lombard-Vadnais F, Gilmore JC, Deshiere A, Gosselin A, Wiche Salinas TR, Bego MG, Power C, Routy JP, Ancuta P, Tremblay MJ, Cohen ÉA. Cell Rep. doi: 10.1016/j.celrep.2017.09.030.

The evaluation of risk-benefit ratio for gut tissue sampling in HIV cure research.

Oct 1, 2017

Mehraj V, Ghali P1, Ramendra R, Costiniuk C, Lebouché B, Ponte R, Reinhard R, Sousa J, Chomont N, Cohen EA, Ancuta P,Routy JP. J Virus Erad. 1;3(4):212-217.

The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters.

Sept 29, 2017

Tietjen I, Ngwenya BN, Fotso G, Williams DE, Simonambango S, Ngadjui BT, Andersen RJ, Brockman MA, Brumme ZL,Andrae-Marobela K. J Ethnopharmacol. 29;211:267-277. doi: 10.1016/j.jep.2017.09.038. [Epub ahead of print]

Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.

Sept 18, 2017

Hassounah SA, Alikhani A, Oliveira M, Bharaj S, Ibanescu RI, Osman N, Xu HT, Brenner BG, Mesplède T, Wainberg MA. Antimicrob Agents Chemorther, 18 sept 2017. doi: 10.1128/AAC.01695-17. [Epub ahead of print]

RNA flow cytometric FISH for investigations into HIV immunology, vaccination and cure strategies.

Sept 12, 2017

Baxter AE, Niessl J, Morou A, Kaufmann DE. AIDS Res Ther 2017 DOI 10.1186/s12981-017-0171-x

Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design.

Sept 12, 2017

Routy JP and Mehraj V. AIDS Res Ther 2017. DOI 10.1186/s12981-017-0164-9

Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.

Sept 7, 2017

Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Massanella M, Brassard N, Alsahafi N, Routy JP, Finzi A, Chomont N,Kaufmann D. Nat Protocol. doi: 10.1038/nprot.2017.079.

Pharmacologic HIV-1 Nef blockade promotes CD8 T cell–mediated elimination of latently HIV-1–infected cells in vitro.

Sept 7, 2017

Mujib S, Saiyed A, Fadel S, Bozorgzad A, Aidarus N, Yun Yue F, Benko E, Kovacs C, Emert-Sedlak LA, Smithgall TE, Ostrowski MA. JCI Insight. DOI: 10.1172/jci.insight.93684.

HIV-1 selectively targets gut-homing CCR6+CD4+ T-cells via mTOR-dependent mechanisms.

Aug 3, 2017

Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P. JCI Insight. doi: 10.1172 /jci.insight.93230.

Comprehensive cross-clade characterization of antibody-mediated recognition, complement-mediated lysis and cell-mediated cytotoxicity of HIV-1 envelope specific antibodies towards the eradication of the HIV-1 reservoir.

Jul 27, 2017

Mujib S, Liu J, Rahman AKMN, Schwartz JA, Bonner P, Yue FY, Ostrowski MA. J Virol. 27;91(16). pii: e00634-17. doi: 10.1128/JVI.00634-17. Print 2017 Aug 15.

HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPase.

Jul 14 2017

Cinti A, Le Sage V, Mirev MP, Valiente-Echeverria F, Crossie C, Miron MJ, Pante N, Oliver M, Mouland AJ. Scientific Reports. 7(1):5515.

Global mapping of the macrophage-HIV-1 transcriptome reveals that productive infection induces remodeling of host cell DNA and chromatin.

Jul 12 2017

Deshiere A, Joly-Beauparlant C, Breton Y, Ouellet M, Raymond F, Lodge R, Barat C, Roy M-A, Corbeil J, Tremblay MJ. Scientific Reports. 7(1):5238.

HIV-1 and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathway.

Jul 11, 2017

Gajanayaka N, O’Hara S, Konarski Y, Fernandes J, Muthumani K, Kozlowski M, Angel JB, Kumar A. J Leukoc Biol. 2017 Sep;102(3):925-939. doi: 10.1189/jlb.4A0716-332RR. Epub 2017 Jul 11.

Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication.

Apr 24, 2017

Sandstrom TS, Ranganath N, Angel JB. Cytokine Growth Factor Rev. 37:1-16. doi: 10.1016/j.cytogfr.2017.04.004. Epub 2017 Apr 24.

Tim-3 is a marker of plasmacytoid dendritic cell dysfunction during HIV infection and is associated with the recruitment of IRF7 and p85 into lysosomes and with the submembrane displacement of TLR9.

Mar 6, 2017

Schwartz JA, Clayton KL, Mujib S, Zhang H, Rahman AK, Liu J, Yue FY, Benko E, Kovacs C, Ostrowski MA. J Immunol. 2017 Apr 15;198(8):3181-3194. doi: 10.4049/jimmunol.1601298. Epub 2017 Mar 6.

HIV-1 Vpu downmodulates ICAM-1 expression resulting in decreased killing of infected CD4+ T cells by NK cells.

Mar 29, 2017

Sugden SM, Pham TN, Cohen EA. Journal of virology, 91(8): e02442-16.

CD4 T follicular helper cells and HIV infection: Friends or enemies?

Feb 20, 2017

Moukambi F, Rodrigues V, Fortier Y, Rabezanahary H, Borde C, Krust B, Andreani G, Silvestre R, Petrovas C, Laforge M, Estaquier J. Frontiers in immunology, 8:135.

HIV persists in CCR6+CD4+ T-cells from colon and blood during antiretroviral therapy.

Jan 2, 2017

Gosselin A, Wiche Salinas TR, Planas D, Wacleche VS, Zhang Y, Fromentin R, Chomont N, Cohen EA, Shacklett B, Mehraj V, Ghali MP, Routy JP, Ancuta P. AIDS2017, 31(1): 35-48.

2016

Ebola virus VP35 blocks stress granule assembly.

Dec 23, 2016

Le Sage V, Cinti A, McCarthy S, Amorim R, Rao S, Daino GL, Tramontano E, Branch DR, Mouland AJ. Virology. 2017 Feb;502:73-83. doi: 10.1016/j.virol.2016.12.012. Epub 2016 Dec 23.

HIV-1 latency-reversing agents prostratin and bryostatin-1 induce blood-brain barrier disruption/inflammation and modulate leukocyte adhesion/transmigration.

Dec 19, 2016

Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ. J Immunol. Feb 1;198(3):1229-1241. doi: 10.4049/jimmunol.1600742. Epub 2016 Dec 19.

Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults.

Nov 28, 2016

Jenabian MA, Costiniuk CT, Mehraj V, Ghazawi FM, Fromentin R, Brousseau J, Brassard P, Belanger M, Ancuta P, Bendayan R,Chomont N, Routy JP; for the Orchid study group. AIDS, 30(18): 2777-2786.

Enhancing virion tethering by BST2 sensitizes productively and latently HIV-infected T cells to ADCC mediated by broadly neutralizing antibodies.

Nov 17, 2016

Pham TN, Lukhele S, Dallaire F, Perron G, Cohen EA. Scientific reports, 6: 37225.

AMPK in Pathogens.

Nov 4, 2016

Mesquita I, Moreira D, Sampaio-Marques B, Laforge M, Cordeiro-da-Silva A, Ludovico P, Estaquier J, Silvestre R. Experientia Supplementum, 107: 287-323.

Differential control of BST2 restriction and plasmacytoid dendritic cell antiviral response by antagonists encoded by HIV-1 group M and O strains.

Oct 28, 2016

Bego MG, Cong L, Mack K, Kirchhoff F, Cohen EA. Journal of virology 2016, 90(22): 10236-10246.

Type I interferon responses are impaired in latently HIV infected cells.

Sept 9, 2016

Ranganath N, Sandstrom TS, Fadel S, Cote SC, Angel JB. Retrovirology 2016, 13(1): 66.

Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.

Aug 18, 2016

Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado G-G,Routy JP, Walker BD, Finzi A, Chomont N, Kaufmann DE. Cell Host Microbe. 2016 Sep 14;20(3):368-380. doi: 10.1016/j.chom.2016.07.015. Epub 2016 Aug 18.

Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection.

Août 12, 2016

Dagenais-Lussier X, Aounallah M, Mehraj V, El-Far M, Tremblay C, Sekaly RP, Routy JP, van Grevenynghe J; for the Montreal Primary Infection Study Group. Journal of virology, 90(17): 7967-7979

Role and modulation of drug transporters in HIV-1 therapy.

May 13, 2016

Alam C, Whyte-Allman SK, Omeragic A, Bendayan R. Adv Drug Deliv Rev. Aug 1;103:121-43. doi: 10.1016/j.addr.2016.05.001. Epub 2016 May 13.

The plasma levels of soluble ST2 as a marker of gut mucosal damage in early HIV infection.

June 19, 2016

Mehraj V, Jenabian MA, Ponte R, Lebouche B, Costiniuk C, Thomas R, Baril JG, Leblanc R, Cox J, Tremblay C, Routy JP, for the Primary HIV Infection and the Long-Term Non-Progressors Study Groups. AIDS 2016, 30(10): 1617-1627.

Adapting the stress response: viral subversion of the mTOR signaling pathway.

Mai 24, 2016

Le Sage V, Cinti A, Amorim R, Mouland AJ. Viruses 2016, 8(6): 152

Indoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory T cells.

Mai 10, 2016

Yun TJ, Lee JS, Machmach K, Shim D, Choi J, Wi YJ, Jang HS, Jung IH, Kim K, Yoon WK, Miah MA, Li B, Chang J, Bego MG, Pham TN, Loschko J, Fritz JH, Krug AB, Lee SP, Keler T, Guimond JV, Haddad E, Cohen EA, Sirois MG, El-Hamamsy I, Colonna M, Oh GT, Choi JH, Cheong C. Cell metabolism 2016, 23(5): 852-866.

Dendritic cell immunotherapy for HIV-1 infection using autologous HIV-1 RNA: a randomized, double-blind, placebo-controlled clinical trial.

Mai 1, 2016

Jacobson JM, Routy JP, Welles S, DeBenedette M, Tcherepanova I, Angel JB, Asmuth DM, Stein DK, Baril JG, McKellar M, Margolis DM, Trottier B, Wood K, Nicolette C. Journal of acquired immune deficiency syndromes 2016, 72(1): 31-38.

Antiretroviral drug transporters and metabolic enzymes in human testicular tissue: potential contribution to HIV-1 sanctuary site.

Avril 13, 2016

Huang Y, Hoque MT, Jenabian MA, Vyboh K, Whyte SK, Sheehan NL, Brassard P, Belanger M, Chomont N, Fletcher CV, Routy JP, Bendayan R. J Antimicrob Chemother. 2016 Jul;71(7):1954-65. doi: 10.1093/jac/dkw046. Epub 2016 Apr 13.

HIV-1 Gag blocks selenite-induced stress granule assembly by altering the mRNA cap-binding complex.

Mar 29, 2016

Cinti A, Le Sage V, Ghanem M, Mouland AJ. mBio 2016, 7(2):e00329-16.

HIV-1-mediated BAFF secretion in macrophages does not require endosomal TLRs, type-I IFN, and Nef, but depends on the cellular phenotype status.

Mar 28, 2017

Gomez AM, Ouellet M, Deshiere A, Breton Y, Tremblay MJ. Journal of immunology 2016, 196(9): 3806-3817.

Bacterial DNA protects monocytic cells against HIV-Vpr-induced mitochondrial membrane depolarization.

Mar 11, 2016

Saxena M, Busca A, Holcik M, Kumar A. Journal of immunology 2016, 196(9): 3754-3767.

Reversing gut damage in HIV infection: using non-human primate models to instruct clinical research.

Jan 26, 2016

Ponte R, Mehraj V, Ghali P, Couedel-Courteille A, Cheynier R, Routy JP. EBioMedicine 2016, 4: 40-49.

2015

Characterization of in vitro generated human polarized macrophages.

Dec 21, 2015

Iqbal S, Kumar A. Journal of clinical & cellular immunology 2015, 6(6): 380.

Early loss of splenic Tfh cells in SIV-infected rhesus macaques.

Dec 7, 2015

Moukambi F, Rabezanahary H, Rodrigues V, Racine G, Robitaille L, Krust B, Andreani G, Soundaramourty C, Silvestre R, Laforge M, Estaquier J. PLoS pathogens 2015, 11(12): e1005287.

Differential evolution of a CXCR4-using HIV-1 strain in CCR5wt/wt and CCR5∆32/∆32 hosts revealed by longitudinal deep sequencing and phylogenetic reconstruction.

Dec 3, 2015

Le AQ, Taylor J, Dong W, McCloskey R, Woods C, Danroth R, Hayashi K, Milloy MJ, Poon AF, Brumme ZL. Scientific reports 2015, 5: 17607.

HIV immunotherapy comes of age: implications for prevention, treatment and cure.

Dec 2, 2015

Routy JP, Mehraj V, Cao W. Expert review of clinical immunology 2016, 12(2): 91-94.

Reversing gut damage in HIV infection: using non-human primate models to instruct clinical research.

Dec 2, 2015

Ponte R, Mehraj V, Ghali P, Couedel-Courteille A, Cheynier R, Routy JP. EBioMedicine 2016, 4: 40-49.

Attacking the supply lines: HIV-1 restricts alanine uptake to prevent T cell activation.

Nov 11, 2015

Sugden S, Cohen EA. Cell host & microbe 2015, 18(5): 514-517.

HIV-1 recruits UPF1 but excludes UPF2 to promote nucleocytoplasmic export of the genomic RNA.

Oct 20, 2015

Ajamian L, Abel K, Rao S, Vyboh K, Garcia-de-Gracia F, Soto-Rifo R, Kulozik AE, Gehring NH, Mouland AJ. Biomolecules, 5(4): 2808-2839.

Challenges and opportunities for T-cell-mediated strategies to eliminate HIV reservoirs.

2 oct 2015

Brockman MA, Jones RB, Brumme ZL. Frontiers in immunology 2015, 6:506.

Characterization of the drug resistance profiles of integrase strand transfer inhibitors in simian immunodeficiency virus SIVmac239.

Sept 16, 2015

Hassounah SA, Liu Y, Quashie PK, Oliveira M, Moisi D, Brenner BG, Sandstrom PA, Mesplede T, Wainberg MA. Journal of virology, 89(23): 12002-12013.

Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation.

Sept 11, 2015

Le Sage V, Cinti A, Valiente-Echeverria F, Mouland AJ. Virology journal 2015, 12(1): 138.

Overcoming the challenge of diagnosis of early HIV infection: a stepping stone to optimal patient management.

Sept 11, 2015

Routy JP, Cao W, Mehraj V. Expert review of anti-infective therapy, 13(10): 1189-1193.

Early initiation rather than prolonged duration of antiretroviral therapy in HIV infection contributes to the normalization of CD8+ T-cell counts.

Sept 8, 2015

Cao W, Mehraj V, Trottier B, Baril JG, Leblanc R, Lebouche B, Cox J, Tremblay C, Lu W, Singer J, Li T, Routy JP, and the Montreal Primary HIV infection Study Group. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016, 62(2): 250-257.

A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion.

Août 28, 2015

Anmole G, Kuang XT, Toyoda M, Martin E, Shahid A, Le AQ, Markle T, Baraki B, Jones RB, Ostrowski MA, Ueno T, Brumme ZL,Brockman MA. Journal of immunological methods 2015, 426: 104-113.

Vpu exploits the cross-talk between BST2 and the ILT7 receptor to suppress anti-HIV-1 responses by plasmacytoid dendritic cells.

Juil 14, 2015

Bego MG, Côté E, Aschman N, Mercier J, Weissenhorn W, Cohen EA. PLoS pathogens 2015, 11(7): e1005024.

CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV-positive patients.

Jun 29, 2015

Lu W, Mehraj V, Vyboh K, Cao W, Li T, Routy JP. Journal of the International AIDS Society, 18: 20052.

Clinical relevance of kynurenine pathway in HIV/AIDS: An immune checkpoint at the crossroads of metabolism and inflammation.

Mai 6, 2015

Routy JP, Mehraj V, Vyboh K, Cao W, Kema I, Jenabian MA. AIDS reviews, 17(2): 96-106.

Impaired Th17 polarization of phenotypically naive CD4+ T-cells during chronic HIV-1 infection and potential restoration with early ART.

Mai 6, 2015

DaFonseca S, Niessl J, Pouvreau S, Wacleche VS, Gosselin A, Cleret-Buhot A, Bernard N, Tremblay C, Jenabian MA, Routy JP,Ancuta P. Retrovirology 2015, 12(1): 38.

HIV-1-triggered release of type I IFN by plasmacytoid dendritic cells induces BAFF production in monocytes.

Mar 1, 2015

Gomez AM, Ouellet M, Tremblay MJ. Journal of immunology, 194(5): 2300-2308.

Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment.

Feb 13, 2015

Juno JA, Stalker AT, Waruk JL, Oyugi J, Kimani M, Plummer FA, Kimani J, Fowke KR. Retrovirology2015, 12(1): 17.

Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection.

Jan 23, 2015

Jenabian MA, El-Far M, Vyboh K, Kema I, Costiniuk CT, Thomas R, Baril JG, LeBlanc R, Kanagaratham C, Radzioch D, Allam O, Ahmad A, Lebouche B, Tremblay C, Ancuta P, Routy JP; for the Montreal Primary infection and Slow Progressor Study Groups. The Journal of infectious diseases 2015, 212:(3): 355-366.

2014

eEF2 and Ras-GAP SH3 domain-binding protein (G3BP1) modulate stress granule assembly during HIV-1 infection.

Sep 17, 2014

Valiente-Echeverría F, Melnychuk L, Vyboh K, Ajamian L, Gallouzi IE, Bernard N, Mouland AJ. Nature communications 2014, 5: 4819

PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF-kB-dependent expression of antiapoptotic Bcl-xL.

Sept 15, 2014

Busca A, Saxena M, Iqbal S, Angel J, Kumar A. Journal of leukocyte biology, 96(6): 1011-1022.

Effect of HIV-1 integrase resistance mutations when introduced into SIVmac239 on susceptibility to integrase strand transfer inhibitors.

Sept 1, 2014

Hassounah SA, Mesplede T, Quashie PK, Oliveira M, Sandstrom PA, Wainberg MA. Journal of virology2014, 88(17): 9683-9692.

A conserved target site in HIV-1 Gag RNA is accessible to inhibition by both an HDV ribozyme and a short hairpin RNA.

Jul 29, 2014

Scarborough RJ, Levesque MV, Boudrias-Dalle E, Chute IC, Daniels SM, Ouellette RJ, Perreault JP, Gatignol A. Molecular therapy nucleic acids, 3: e178.

An evaluation of phylogenetic methods for reconstructing transmitted HIV variants using longitudinal clonal HIV sequence data.

Mar 19, 2014

McCloskey RM, Liang RH, Harrigan PR, Brumme ZL, Poon AF. Journal of virology, 88(11): 6181-6194.

From arrest to escape: HIV-1 Vpr cuts a deal.

Feb 12, 2014

Cohen EA. Cell host & microbe 2014, 15(2): 125-127

HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2.

Feb 6, 2014

Pham TN, Lukhele S, Hajjar F, Routy JP, Cohen EA. Retrovirology 2014, 11: 15

Deamination intensity profiling of human APOBEC3 protein activity along the near full-length genomes of HIV-1 and MoMLV by HyperHRM analysis.

Jan 4, 2014

Belanger K, Savoie M, Aydin H, Renner TM, Montazeri Z, Langlois MA. Virology 2014, 448: 168-175.

2013

Role of P-glycoprotein in the distribution of the HIV protease inhibitor atazanavir in the brain and male genital tract.

Dec 30, 2013

Robillard KR, Chan GN, Zhang G, la Porte C, Cameron W, Bendayan R. Antimicrobial agents and chemotherapy, 58(3): 1713-1722.

Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells.

Dec 23, 2013

Rhee I, Zhong MC, Reizis B, Cheong C, Veillette A. Molecular and cellular biology 2014, 34(5): 888-899.

Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replication.

Dec 21, 2013

Bernier A, Cleret-Buhot A, Zhang Y, Goulet JP, Monteiro P, Gosselin A, DaFonseca S, Wacleche VS, Jenabian MA, Routy JP, Tremblay C, Ancuta P. Retrovirology 2013, 10: 160.

Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells.

Nov 28, 2013

Mollah SA, Dobrin JS, Feder RE, Tse SW, Matos IG, Cheong C, Steinman RM, Anandasabapathy N. The Journal of investigative dermatology, 134(5): 1265-1275.

Efficient BST2 antagonism by Vpu is critical for early HIV-1 dissemination in humanized mice.

Nov 6, 2013

Dave VP, Hajjar F, Dieng MM, Haddad E, Cohen EA. Retrovirology 2013, 10: 128.

Selective recognition of viral promoters by host cell transcription complexes: challenges and opportunities to control latency.

Juil 1, 2013

Wilhelm E, Bell B. Current opinion in virology 2013, 3(4): 380-386

Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.

Juin 14, 2013

Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, Bordi R, Procopio FA, Miura T, Allen TM, Sidney J, Sette A, Walker BD, Ahmed R, Boss JM, Sekaly RP, Kaufmann DE. Journal of immunology 2013, 191(2): 540-544.

Interleukin-7 promotes HIV persistence during antiretroviral therapy.

Avril 15, 2013

Vandergeeten C, Fromentin R, DaFonseca S, Lawani MB, Sereti I, Lederman MM, Ramgopal M, Routy JP, Sekaly RP, Chomont N. Blood 2013, 121(21): 4321-4329.

2012

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.

Dec 11, 2012

Ndhlovu ZM, Chibnik LB, Proudfoot J, Vine S, McMullen A, Cesa K, Porichis F, Jones RB, Alvino DM, Hart MG, Stampouloglou E, Piechocka-Trocha A, Kadie C, Pereyra F, Heckerman D, De Jager PL, Walker BD, Kaufmann DE. Blood 2013, 121(5): 801-811.

Role of drug efflux and uptake transporters in atazanavir intestinal permeability and drug-drug interactions.

Dec 7, 2012

Kis O, Zastre JA, Hoque MT, Walmsley SL, Bendayan R. Pharmaceutical research 2013, 30(4): 1050-1064.

Modulation of HIV reservoirs by host HLA: bridging the gap between vaccine and cure.

Aout 29, 2012

Brumme ZL, Chopera DR, Brockman MA. Current opinion in virology 2012, 2(5): 599-605.

Exon level transcriptomic profiling of HIV-1-infected CD4(+) T cells reveals virus-induced genes and host environment favorable for viral replication.

Aout 2, 2012

Imbeault M, Giguere K, Ouellet M, Tremblay MJ. PLoS pathogens 2012, 8(8): e1002861.

CTGC motifs within the HIV core promoter specify Tat-responsive pre-initiation complexes.

Juil 26, 2012

Wilhelm E, Doyle MC, Nzaramba I, Magdzinski A, Dumais N, Bell B. Retrovirology, 9: 62.

Towards an HIV cure: a global scientific strategy.

Juil 20, 2012

The International AIDS Society Scientific Working Group on HIV Cure: Deeks SG, Autran B, Berkhout B, Benkirane M, Cairns S, Chomont N, Chun TW, Churchill M, Di Mascio M, Katlama C, Lafeuillade A, Landay A, Lederman M, Lewin SR, Maldarelli F, Margolis D, Markowitz M, Martinez-Picado J, Mullins JI, Mellors J, Moreno S, O'Doherty U, Palmer S, Penicaud MC, Peterlin M, Poli G, Routy JP, Rouzioux C, Silvestri G, Stevenson M, Telenti A, Van Lint C, Verdin E, Woolfrey A, Zaia J, Barre-Sinoussi F. Nature reviews immunology, 12(8): 607-614.

Differential HIV-1 endocytosis and susceptibility to virus infection in human macrophages correlate with cell activation status.

Juil 11, 2012

Gobeil LA, Lodge R, Tremblay MJ. Journal of virology 2012, 86(19): 10399-10407.